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IntroductionThe conversion of epithelial to mesenchymal cells, called EMT, has important functions in cell differentiation and organogenesis. What's more, it increases tissue repair and to disease, with changes in EMT involving tissue fibrosis, immunosuppression and carcinogenesis (Thiery et al, 2009). EMT involves striking cellular changes, including loss in cell adhesion and polarity and gain of migratory and invasive properties. Wnt and TGF initiate, amplify and modulate EMT, inducing gene expression changes that induce the cell's phenotypic transitions (Thiery and Sleeman, 2006; Thiery et al, [url=http://www.educaguia.com/educaguia.html]Botas Ugg España[/url] 2009). Thus, activation of [url=http://www.educaguia.com/educaguia.html]UGG España[/url] transcriptional regulators the same as Snail and transcriptional changes for example downregulation of Ecadherin or upregulation of Vimentin are classical landmarks of EMT. The image emerging in the work of Warzecha et al (2010) during this publication of the EMBO Journal and also a previous report on the Carstens' group (Warzecha et al, 2009) is that alternative splicing offers [url=http://www.educaguia.com/educaguia.html]Ugg España[/url] an additional layer of gene regulation that contributes to shape the EMT process.
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